MyBioSource.com's PIAS4 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The PIAS4 Antibody was generated using PIAS4 as the antigen and it reacts with Human, and Mouse.
Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.Zendra E. Zehner, AACR Meeting Abstracts, Apr 2005; 2005: 456. Amador Albor, J. Biol. Chem., Sep 2006; 281: 25850 - 25866. Christina-Maria Hecker, J. Biol. Chem., Jun 2006; 281: 16117 - 16127. Yun Zhao, Stem Cells, Apr 2007; 10.1634